Search. The phase IV clinical study is created by eHealthMe based on reports from the FDA, and is updated regularly. However, no difference was found when EDTA was used. The adhesiveness of blood platelets in thromboembolism and hemorrhagic disorders; measurement of platelet adhesiveness by the glass-wool filter. BibSonomy. ( en | de | ru ) tag. 3: SYNONYM: 1;0: Multiple #61.51 : 61.51. Platelet adhesiveness shows a maximum at a velocity of 7 cm/sec. Made available by U.S. Department of Energy Office of Scientific and Technical Information . The. Share to Reddit. b) a cycle of NREM sleep, followed by a cycle of REM sleep, then wakefulness. A full night's sleep is characterized by. Adenosine Diphosphate and the Measurement of Platelet Adhesiveness Journal of Clinical Pathology. However, wewere concerned to develop a simple method of estimating platelet adhesiveness with areproducible Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. The adhesiveness of human blood platelets in vitro. Share to Tumblr. 0 Ratings 0 Want to read; 0 Currently reading; 0 Have read; Donate this book to the Internet Archive library. "Platelet Adhesiveness" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. These events include shape change, adhesiveness, aggregation, and release reactions. 19, Iss: 8, pp 701-709 Yoshida sarcoma cells adhere better at low flow . With medical big data and AI . activate platelets in vitro and in vivo and several mechanisms have been suggested to account for this. PROPERTIES OF PLATELETS, ADHESIVENESS Platelets have three key characteristics (the three With medical big data and AI algorithms . 1:34. Video encyclopedia. au:"Mycielska, Maria E" (27) : 20 | 50 | 100 20 | 50 | 100. When sodium citrate was used platelet adhesiveness was significantly greater in the group with ischaemic heart disease. 2. No dependence of lymphocyte adhesiveness was shown for divalent cations, cyanide, dinitrophenol, or iodoacetamide, but such dependence is not excluded by the data obtained. The duration of centrifugation used in the preparation of platelet-rich plasma was found to have a profound effect on the measurement of platelet adhesiveness because the figure for platelet adhesiveness measured in platelet-rich plasma obtained by centrifugation was considerably lower than that found in citrated whole blood. ADENOSINE diphosphate (ADP) is known to cause reversible aggregation of human and animal platelets in vitro1-4. abstract: the following methods were used to measure the adhesion to various surfaces of platelets in whole blood or plasma: 1, two measurements gave an estimate in vivo of platelet adhesion to cut human capillaries; 2, platelets adhering to damaged cells in vitro were counted directly; 3, a highly reproducible method for estimating platelet 0:16. No report of Platelet adhesiveness increased is found in people who take Apadaz. }, author={W J{\"a}ger and Joerg Kutschera and Hans Wendeberg and Roland Kauschmann and Werner Tw de Riese and U. Pietsch and E Berger and Christine Bennert}, journal={Blut}, year={1974 . Platelets show a characteristic velocity profile. Indices of platelet adhesiveness in vitro were obtained from 10 nonpregnant women, 25 normal pregnant women, 10 with essential hypertension, 10 with m Consequently, LAD-III platelets failed to aggregate because of an impaired IIb3 activation by key . d) four to five sleep cycles of about 90 minutes each. Smoking decreases plaque formation. @article{Jger1974TheCM, title={[The continuous measurement of platelet aggregation without addition of aggregation stimulators. by Arvid John Hellum. More . 1 - 20 de 27 The blue social bookmark and publication sharing system. 2006: Blood: 107: 2728-35: 16357324: Naik MU The greatest increase in . The effect from anti-platelet drugs like dipyridamole and acetyl salicylic acid in preventing increase of platelet adhesiveness due to a biologic stressor are compared with those obtained with isoxsuprine. Synthetic cross-linked collagen-related peptide (CRP-XL) is a glycoprotein VI (GPVI) receptor activator for platelet activation. Hellem et al.5 used a column of glass beads 6 to determine an increase, within. "Effect of Dipyridamole and Two Pyrimido-pyrimidine Derivatives On the Kinetics of Human Platelet Aggregation and On Platelet Adhesiveness." Scandinavian Journal of Clinical and Laboratory Investigation, vol. Using this method, we demonstrated that, in the early stages of acute pancreatitis, platelet adhesiveness and aggregation is increased, contributing to the prethrombotic potential of the disease. platelet adhesiveness translation in English - French Reverso dictionary, see also 'plate',plateful',plated',platter', examples, definition, conjugation Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. Results of an in vitro test in about 600 patients with various diseases are given. In thyrotoxicosis the platelet adhesiveness was significantly increased, but decreased to normal after treatment. Platelets aggregate in the first few seconds only, whereas Yoshida sarcoma cells accumulate continuously. tag; user; group; author; concept; BibTeX key; search Sylvan E. Moolten , Leo Vroman 01 Aug 1949 - American Journal of Clinical Pathology (Am J Clin Pathol) - Vol. a. Semantic Scholar extracted view of "Platelet adhesiveness in Hageman trait." by P. N. Walsh. The maintenance of vascular tone, cell adhesiveness, platelet aggregation, leukocyte trafficking, coagulation cascade, inflammation, . Platelet adhesiveness was measured by the rotating bulb method (Wright 1941); platelet counts were made by the modified Rees-Ecker method in the initial blood sample and after rotation for 10, 20, and 40 minutes. The principle of the method is that special polymer particles of defined size are added to citrate-anticoagulated whole blood. Hematocrit: ratio of volume of red blood cells to total blood volume. D. Replacement of all of the affected platelets is not required to produce normal clotting. Share to Pinterest. the following methods were used to measure the adhesion to various surfaces of platelets in whole blood or plasma: 1, two measurements gave an estimate in vivo of platelet adhesion to cut human capillaries; 2, platelets adhering to damaged cells in vitro were counted directly; 3, a highly reproducible method for estimating platelet adhesion to The phase IV clinical study is created by eHealthMe based on reports from the FDA, and is updated regularly. . When carried through to completion, these events lead to the formation of a stable hemostatic plug. "Platelet Adhesiveness" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. Translations in context of "platelet adhesiveness" in English-French from Reverso Context: The long-term physiological effects: Contribute, along with CO, resistance and platelet adhesiveness. View PROPERTIES OF PLATELETS, ADHESIVENESS- Psyh Midterm PrepNotes.docx from PHYS 1027 at Algoma University. Platelet indices such as platelet count, mean platelet volume (MPV), platelet distribution width (PDW), and platelet large cell ratio . LAST EDITED: DEC 22, 1989 DESCRIPTION: If a result of a procedure should be prompted for, enter 'Yes'. Login The PRP is then centrifuged at 400xg for 20min at RT. 2:08. A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. including (1) direct activation by hemoglobin, (2) increase in reactive oxygen species (ROS), (3) scavenging of nitric oxide by released hemoglobin, and (4) release of intraerythrocytic ADP. After approximately 20% of the platelets have been replaced with newly formed platelets, clotting will return to normal by approximately 36 hours. I. These studies suggest that lipopolysaccharide stimulates polymorphonuclear leukocytes to produce thromboxane A 2, which enhances their adhesiveness to nylon. All three measurements were significantly abnormal in the diabetic patients. Platelet Adhesion and Spreading on a Fibrinogen Matrix. It may or may not be enhanced when the blood is hypercoagulable. See also [ edit] Platelet membrane glycoprotein References [ edit] The increase in platelet adhesiveness was capable of distinguishing the diabetics on a group basis, but not on individual results. Results of Parasitological Examinations of Faecal Samples From Cats and Dogs in Germany Between 2003 and 2010 Parasitology Research. In hypothyroidism platelet adhesiveness was abnormally low but increased to normal value after thyroid hormone replacement. 2, 1969, pp. Platelet adhesiveness was measured in vitro in a group of patients with ischaemic heart disease and in a group of matched healthy subjects using either 1% EDTA or 3.8% sodium citrate as anticoagulant. D. Approximately how many non-smokers die of heart disease each year due to exposure to ETS (environmental tobacco smoke)? Platelet count was then adjusted Rheometer (TA instruments) (n = 3) to evaluate the materials to a desired concentration of 106 /L, using plasma. In hemophilia, the adhesiveness of platelets has been found to become increased beyond the premedication level when the coagulation defect is corrected by Fraction 1 derived from human plasma. 1967 English. This test is capable of clearly demonstrating the defect in platelet. Share to Twitter. Methods and clinical results]. Adhesiveness of platelets is reduced in the presence of hypocoagulable blood. No report of Platelet adhesiveness decreased is found for people with Tinea of the scalp. concept Search across key concepts extracted from titles and abstracts matching text Search across indexed text content in Pure, such as names, titles, descriptions etc. Healthy = 45% RBC Anemia: decreased RBC numbers; caused by: Iron or Vitamin B12 deficiency Loss of blood Pregnancy Sickle Cell Anemia: genetic disorder Cells take on sickle shape, become sticky Can slow or stop blood flow in narrow capillaries Sickle cells die in 10-20 days, leaving you with low RBC count Blood Composition . This triple helical peptide, widely used in platelet function tests, is synthesized and cross-linked through cysteine residues at its N-terminus and C-terminus. Ristocetin-induced platelet aggregation (RIPA) or platelet binding; VWF propeptide (VWFpp) to VWF antigen . Platelet adhesiveness and the levels of two coagulation factors, fibrinogen and factor VIII, were studied in a series of diabetic and nondiabetic control subjects. Furthermore, we demonstrated the potential usefulness of PFA-100TM in studying thrombotic states. Sign In Create Free Account. Rabbits Blood-Borne Pathogens Mice, Inbred C57BL Dogs Mice, Knockout. Meaning of platelet adhesiveness. 24, no. The following methods were used to measure the adhesion to various surfaces of platelets in whole blood or plasma: 1, two measurements gave an estimate in vivo of platelet adhesion to cut human capillaries; 2, platelets adhering to damaged cells in vitro were counted directly; 3, a highly reproducible method for estimating platelet adhesion to glass was devised; 4, the manner in . Health Conditions. The PADA test can be used as a bedside test or point-of-care test and quantitatively measures platelet adhesiveness. 35,000 The Adhesiveness Of Human Blood Platelets On Vitro Item Preview remove-circle Share or Embed This Item. Organisms 5. The first signaling molecule for PMNs to be identified as a product of stimulated endothelial cells, platelet-activating factor , is a biologically-active phospholipid (7, 10). Diseases 49. The first aggregation test introduced into laboratory practice used platelet-rich plasma (PRP) where aggregation was detected by an optical method.Platelet aggregation assessment by the use of whole blood aggregation tests with collagen or ADP was performed in these patients and 30 age. No report of Platelet adhesiveness decreased is found in people who take Linzess. c) four to five sleep cycles of about 45 minutes each. 2000: J Clin Invest: 106: 385-92: 10930441: Bernardi B: The small GTPase Rap1b regulates the cross talk between platelet integrin alpha2beta1 and integrin alphaIIbbeta3. Medicine Forensic Medicine Pathology. These studies identify CalDAG-GEFI as a critical regulator of inside-out integrin activation in human T lymphocytes, neutrophils, and platelets. a) four to five sleep cycles of about 60 minutes each. References A method for rendering an article made from a polymeric material non-thrombogenic comprising chemically binding a platelet anti-aggregative agent selected from the group consisting of 4,5-diphenyl-2-bis-(2-hydroxyethyl)amino oxazole and 4,8-dipiperidino-2,6-diethanolamino-pyrimido-5, 4-d pyrimidine to the surface of said polymeric material.2. [24-26] Cerebral malaria (CM) as a severe symptom can occur when iRBC, as well as platelets and microparticles, cytoadhere to the vascular endothelium in order to sequester in the brain of the patient. Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. PMN adhesiveness is induced by r(h) ENA-78, r(h) IL-8, and by factors secreted by HUVEC stimulated with IL-1. To form the adhesiveness, which is an important feature for skin tissue PRP gel, CaCl2 solution was added to PRP samples up to a final engineered constructs (Salamone et al., 2016; Qu et al., 2018 . Chemokine-triggered VLA-4 adhesiveness in T lymphocytes was partially defective as well. The fibrinogen in the sample attaches itself to these particles and thus binds the platelets. Incorrect choices: Aspirin irreversibly interferes with the clotting mechanism by reducing platelet adhesiveness. Lipopolysaccharide-stimulated purified platelets did not increase leukocyte adherence, whereas thrombin-stimulated platelets did increase adherence. Smoking decreases the adhesiveness of platelets. Inthis papernoattempthasbeen madeto comparethe degree ofadhesiveness found in normal donors using each technique. With medical big data and AI algorithms . MOOLTEN SE, VROMAN L. Am J Clin Pathol, 19(8):701-709, 01 Aug 1949 Cited by: 34 articles | PMID: 18135498 Platelets were largely retained by the glass bead columns under most conditions and this was unrelated to temperature in the range 0-50C. The platelet-rich plasma (PRP) then needs to be removed and PGE1 was added to the PRP to prevent exogenous platelet activation. 112] and increase in vWF-platelet adhesiveness , results which were similar to findings in T2DM . d. Smoking reduces the level of high-density lipoproteins. Platelet adhesiveness is the adhesion of platelets to other structures. Blood Platelets Megakaryocytes Plasma Cytoplasmic Granules Platelet-Rich Plasma Erythrocytes Leukocytes Cell Membrane Neutrophils Endothelium, Vascular Granulocytes Cells, Cultured. "Platelet Adhesiveness" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Given the minimal average thicknesses of contr Flashback Categories. It is updated regularly. Skip to search form Skip to main content Skip to account menu. Abstract. DESCRIPTION: This is . 145-51. These problems may be solved by making surfaces more "friendly" toward platelets, and by using different drugs. b. Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen. The study is created by eHealthMe and uses data from the Food and Drug Administration (FDA). Eliasson, R, and S Bygdeman. Experimental in vitro, insulin has antagonistic effects on PRP activation in healthy humans. . [1] It can be contrasted with platelet aggregation, [citation needed] which refers to the processes or factors which lead to the adhesion of platelets to other platelets. The adhesiveness of blood platelets in thromboembolism and hemorrhagic disorders; measurement of platelet adhesiveness by the glass-wool filter. the adhesiveness observed by different methods, as these may well measure different aspects of platelet function. Platelet adhesion is an essential function in response to vascular injury and is generally viewed as the first step during which single platelets bind through specific membrane receptors to cellular and extracellular matrix constituents of the vessel wall and tissues. Information and translations of platelet adhesiveness in the most comprehensive dictionary definitions resource on the web. . Search 206,589,055 papers from all fields of science. the following methods were used to measure the adhesion to various surfaces of platelets in whole blood or plasma: 1, two measurements gave an estimate in vivo of platelet adhesion to cut human capillaries; 2, platelets adhering to damaged cells in vitro were counted directly; 3, a highly reproducible method for estimating platelet adhesion to Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. Semantic Scholar's Logo. This may be an important factor in precipitating myocardial infarction in patients with hypothyroidism and . Various platelet adhesiveness test methods are discussed. Platelet adhesiveness. Featured. Comparing platelet adhesiveness and cancer cell stickiness under the conditions of the so-called Fibre test showed that: 1. c. Smoking decreases blood pressure. Direct platelet adhesion potentiates group 2 innate lymphoid cell functions . Share via email. Application of these methods to a number of macromolecular species shows, in general, that features which are only occasionally or marginally detected in bright field may be visualized clearly and consistently through the use of dark-field illumination. Platelet Activation and Factors for Clot Formation. Ascorbic acid was measured in a few samples of plasma by the micromethod of Raiha (1958) modified for 0-5 ml. The median platelet adhesiveness in a defined population of normal adults was 74% and the range of normal was 35 to 94%. Breast Cancer; IBD ; Migraine; Multiple Sclerosis (MS) Rheumatoid Arthritis Platelet adhesiveness is the adhesion of platelets to other structures. Platelet adhesiveness to foreign surfaces and its sequelae is one of the limiting factors for prolonged extracorporeal circulation and adds to the morbidity after implantation of foreign material in the circulation. Share to Facebook.
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